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Drug metabolism
Simcyp allows you to extrapolate in vivo metabolic clearance from routine in vitro data generated during drug development using a variety of systems, including human liver microsomes (HLM), human intestinal microsomes (HIM), human hepatocytes (HHEP) and recombinant cytochrome P450 and UGT enzymes (rCYP, rUGT).
The in vitro intrinsic clearance (CLint) of a compound can be determined either from the enzyme kinetic parameters Vmax and Km or, more simply, from the rate of metabolism at a single substrate concentration, provided it is much lower than the Km value.
A unique feature of the Simcyp platform is that it allows the prediction of the dispersion of hepatic clearance in a population.
To do this effectively requires values of several system specific
scaling factors.
