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Disease populations
The population libraries within the Simcyp Simulator include information on the demographics of various disease groups and the associated modifications in physiology and enzymology. This allows pharmacokinetic behaviour to be predicted in representative virtual patient populations, rather than an ‘average’ healthy male subject. For example, simulations can be performed in virtual populations of patients with liver cirrhosis (mild, moderate or severe) or renal impairment (moderate or severe). The effects of obesity (BMI 30-40 kg/m2) and morbid obesity (BMI > 40 kg/m2) on pharmacokinetic behaviour can also be simulated.
In addition, a typical population of healthy subjects is also defined within the Simulator, allowing virtual ‘Phase I’ pharmacokinetic studies to be simulated.
