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In response to the wishes of the Consortium, the Simcyp R&D team has expanded the functionality of the Simulator to allow pharmaceutical researchers to model and simulate pharmacodynamic (PD) responses.
The original version of Simcyp’s PD module was released in 2010 and allowed assessment of direct concentration-response relationships with propagation of inter-individual variation in pharmacokinetics. The module has since been developed to accommodate transduction through intermediate modulators allowing more mechanistic binding-activation and stimulus-response relationships to be explored.
PD simulations can be set up for one or more compounds, including inhibitors and metabolites, and any PK compartment within the Simcyp Simulator can be used as an input ‘organ’ to drive the PD response. In addition, automated sensitivity analysis and parameter estimation can also be applied to PD simulations.