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Distribution
Simcyp allows the prediction of drug distribution characteristics at several levels:
- Prediction of Vss from drug lipophilicity and plasma protein binding data.
- Prediction of drug concentration-time profiles in blood and tissues based on a full (14 organ) physiologically-based pharmacokinetic (PBPK) model (Figure 3).
Figure 3. Whole body PBPK model.
The information contained within the Simcyp Simulator's databases (validated estimates of tissue volumes and organ blood flow rates in males and females, and in children) allows you to estimate variability in the volume of distribution of a compound in a population.
