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Lung absorption
A first order absorption model is used within the Simcyp Simulator to describe absorption across the lung for any substrate and/or inhibitors. This model can be used with the full physiologically-based pharmacokinetics (PBPK) model as well as the one-compartment distribution model.
When determining the dosing scheme, the user assigns the proportion of the dose which is inhaled; the remaining dose is swallowed. The inhaled dose goes directly to the lungs where absorption is simulated. The proportion of the dose which is swallowed goes to the GI tract where oral absorption can be simulated using any of the Simcyp oral absorption models (first order, CAT and ADAM).
