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Nov 2011
A user-friendly physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain.
26th JSSX Annual Meeting
Tokyo, Japan 20th-22nd November 2012
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Nov 2011
Predicting the effect of CYP2D6 polymorphism on pharmacodynamic response to metoprolol.
PKUK 2011
Durham, UK 9th-11th November 2011
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Oct 2011
Development and application of an In Silico pharmacokinetic 'post bariatric surgery model' in a morbidly obese population to assess drug absorption and metabolism from the gastrointestinal tract.
AAPS Annual Meeting
Washington, DC, USA 23rd-27th October 2011
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Oct 2011
A mechanistic model for the prediction of human-equilibrium blood-to-plasma concentration ratio (B/P): basic and neutraL drugs.
AAPS Annual Meeting
Washington, DC, USA 23rd-27th October 2011
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Oct 2011
A performance evaluation of Simcyp Dog - a fully mechanistic physiologically-based pharmacokinetic dog model - based upon a variety of celecoxib IV and oral formulations.
AAPS Annual Meeting
Washington, DC, USA 23rd-27th October 2011
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Oct 2011
P-gp efflux has no impact on dose proportionality of digoxin bioavailability over a dose range of 0.125 to 1.5 mg: the outcome of a new PBPK model, that includes the in vitro transporter information, is consistent with the clinical observations.
Annual Congress for Clinical Pharmacology
Zurich, Switzerland, 20th-22nd October 2011
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Oct 2011
An investigation into the prediction of in vivo clearance for a range of aldehyde oxidase substrates using a mechanistic population-based pharmacokinetic model.
17th North American ISSX Meeting
Atlanta, GA, USA 16th-20th October 2011
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Aug 2011
A performance evaluation of Simcyp Dog - a full mechanistic physiologically based pharmacokinetic dog model - based upon a variety of theophylline IV and oral formulations.
8th World Congress on Alternative & Animal Use in the Life Sciences
Montreal, Canada, 21st-25th August 2011
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Jun 2011
Prediction of diclofenac pharmacokinetics using earl drug discovery in vitro data in a mechanistic dog physiologicallybased pharmacokinetic model - 'Simcyp Dog'.
3rd Pharm Sci Fair
Prague, Czech Republic, 13th-17th June 2011
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Jun 2011
Sources of inter-individual variability in IVIVE of clearance. An investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model.
3rd Pharm Sci Fair
Prague, Czech Republic, 13th-17th June 2011
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Jun 2011
A physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain.
PAGE Meeting 2011
Athens, Greece, 7th-10th June 2011
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May 2011
Predicting the effect of interlukin-6, an inflammatory cytokine, on time-dependent reduction of cyclosporine clearance: an application of the Simcyp Population-Based Simulator to suppression of CYP450 by biologics.
AAPS National Biotechnology Conference
San Francisco, USA, 16th-18th May 2011
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Apr 2011
Prediction of differences in pharmacokinetics between Chinese and Caucasian populations using a mechanistic physiologically-based pharmacokinetic model.
Asia Pacific ISSX-4
Tainan City, Taiwan, 22nd-26th April 2011
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Apr 2011
Modelling the effect of interleukin-6, an inflammatory cytokine, on time-dependent reduction of cyclosporine clearance: an application of the Simcyp Population-based Simulator to suppression of CYP450 by biologics.
ACoP 2011 Meeting
San Diego CA, USA, 3rd-7th April 2011
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Apr 2011
Combining in vitro-in-vivo extrapolation (IVIVE) and physiologically-based pharmacokinetics (PBPK) with drug related risk assessment: putting pieces together for a priori assessment of the likelihood of cardiotoxicity.
ACoP 2011 Meeting
San Diego CA, USA, 3rd-7th April 2011
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Mar 2011
Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "advanced dissolution, absorption, metabolism (ADAM)" model.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
Physiologically-based pharmacokinetics (PBPK) with and without diffusion limited permeability: modelling drug concentration-time profile in brain.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
Interplay of transport and metabolism in the gut: predictions of drug-drug interactions using physiologically based pharmacokinetic modelling.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
Prediction of OAPP1B1-mediated drug-drug interaction between repaglinide and cyclosporine using physiologically based pharmacokinetic (PBPK) modelling.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
A bottom-up approach to predicting the pharmacokinetics (PK) of theophylline (theo) and its interaction with fluvoxamine (fluv) in liver cirrhosis.
112th ASCPT Meeting
Dallas TX, USA, 2nd-5th March 2011
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Mar 2011
Prediction of the increase in systematic exposure of paroxetine in patients with renal impairment.
112th ASCPT Meeting
Dallas TX, USA, 2nd-5th March 2011
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Feb 2011
Drug clearance in obese patients: shall we expect variations?
National Obesity Forum, Northwest Chapter Obesity Training Day
Salford Royal Hospital, Salford, 1st February 2011
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Nov 2010
Simulation of virtual human subjects to investigate the impact of CYP2C19*17/*17 on omeprazole exposure.
PSWC / AAPS Meeting
New Orleans, USA, 13th-19th November 2010
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Nov 2010
Prediction of Vss and tissue concentration-time profiles for four benzodiazepines using physicochemical, in vitro and experimental data in rat using a mechanistic PBPK model.
PSWC / AAPS Meeting
New Orleans LA, USA, 13th-19th November 2010
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Sep 2010
A time-varying physiologically-based pharmacokinetic model of caffeine during pregnancy.
DMDG Meeting
Canterbury, UK, 15th-17th September 2010
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Sep 2010
Prediction of Vss and tissue concentration-time profiles for four benzodiazepines using physicochemical, in vitro and experimental data in rat using a mechanistic PBPK model.
11th Annual Simcyp Consortium Meeting
Sheffield, UK, 19th-21st September 2010
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Sep 2010
Prediction of human intestinal metabolism of CYP3A substrates using the Advanced, Dissolution, Absorption and Metabolism (ADAM) Model.
11th Annual Simcyp Consortium Meeting
Sheffield, UK, 19th-21st September 2010
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Jun 2010
Predicting pharmacokinetics for two NSAIDs commonly used in paediatrics using a physiologically-based model: comparing in vitro data, in vivo data from adults, or their combination as input parameters.
CAPKR Annual Research Meeting
Manchester, UK, 24th-25th June 2010
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Sep 2009
Comparison of in vitro and in vivo metabolic clearance estimates for the prediction of caffeine and theophylline pharmacokinetics in adults, children and neonates using a physiologically based model.
DMDG Meeting
Cambridge, UK, 17th September 2009
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Sep 2009
Prediction of human pharmacokinetics following dermal administration: intergration of a skin absorption module to the Simcyp Population-Based ADME Simulator with the aim of avoiding animal studies.
7th World Congress on Alternative & Animal Use in the Life Sciences
Rome, Italy, 30th August-3rd September 2009
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Feb 2009
The effect of p-glycoprotein (MDR1/ABCB1) on human gut wall absorption depends on physiochemical characteristics of the drug and dosage formulation; simulation of "fa" for digoxin, quinidine and talinolol.
LogP 2009
Zurich, Switzerland, 8th-11th February 2009
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Feb 2009
Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.
DMDG Meeting
Stevenage, UK, 6th February, 2009
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Nov 2008
Theoretical assessment of metabolic drug interactions in paediatric population: the impact of age related fractional metabolism (fm) and its disparity between adults and neonates.
PKUK Meeting
London, UK, 26th-28th November 2008
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Oct 2008
Prediction of time-dependent CYP3A4-mediated in vivo drug-drug interactions from in vitro data using biological information on enzyme turnover implemented within a physiologically based model.
15th North American ISSX Meeting
San Diego, USA 12th-16th October 2008
Abstract published in:
Drug Metabolism Reviews
A184, 40(3), 131-132, 2008
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May 2008
Prediction of the increased exposure to drugs in liver cirrhosis: a systems biology approach integrating prior information on disease with in vitro data on drug disposition.
10th European ISSX Meeting
Vienna, Austria, 18th-21st May
Abstract published in:
Drug Metabolism Reviews
A95, 40(1), 63-64, 2008
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May 2008
Prediction of the in vivo behaviour of modified release formulations of metoprolol from in vitro dissolution profiles using the ADAM model (Simcyp V8).
10th European ISSX Meeting
Vienna, Austria, 18th-21st May 2008
Abstract published in:
Drug Metabolism Reviews
A72, 40(1), 45-46, 2008
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May 2008
Simulation of the effect of P-glycoprotein on drug absorption in the human gastrointestinal tract.
10th European ISSX Meeting
Vienna, Austria, 18th-21st May 2008
Abstract published in:
Drug Metabolism Reviews
A236, 40(1), 169-170, 2008
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May 2008
In vitro-in vivo extrapolation of the clearance of drugs by glucuronidation: scaling factors for recombinant UGT1A1 data.
10th European ISSX Meeting
Vienna, Austria, 18th -21st May 2008
Abstract published in:
Drug Metabolism Reviews
A188, 40(1), 133-134, 2008
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May 2008
Cytochrome P450 turnover: methods for determining rates and implications for the prediction of drug interactions.
2nd Asian Pacific ISSX Meeting
Shanghai, China, 11th-13th May 2008
Abstract published in:
Drug Metabolism Reviews
A93, 40(2), 59, 2008
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May 2008
Comparison of the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9: determination of inter system extrapolation factors.
10th European ISSX Meeting
Vienna, Austria, 18th-21st May 2008
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May 2008
What is the level of expression of CYP2D6 in human liver? Influence of different calibration standards of the estimation of CYP2D6 abundance.
10th European ISSX Meeting
Vienna, Austria, 18th-21st May 2008
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Mar 2008
Mechanistic models of human pharmacokinetics to predict the effects of liver cirrhosis on the clearance of nine drugs.
American Conference on Pharmacometrics
Tucson, USA, 9th-12th March 2008
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Oct 2007
Supersaturation properties of poorly soluble weak bases are key factors in determining oral drug absorption: a simulation study of nifedipine using the ADAM model (Simcyp V7.1).
EUFEPS & COST B25 Conference
Athens, Greece, 1st-2nd October 2007
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Oct 2007
Impact of variability in estimates of drug diffusion coefficient on the prediction of fraction absorbed from the gut (fa) using the ADAM model (Simcyp V7.1).
EUFEPS & COST B25 Conference
Athens, Greece, 1st-2nd October 2007
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Sep 2007
Experimental considerations in determining Inter System Extrapolation Factors required for prediction of human drug clearance from recombinantly expressed enzymes.
DMDG Open Meeting.
Cambridge, UK, 2007
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Jun 2007
A novel physiologically-based mechanistic model for predicting oral drug absorption: the advanced dissolution, absorption, and metabolism (ADAM) model.
4th WCDATD
Kanazawa, Japan, 20th-22nd June 2007
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Jun 2007
Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.
4th WCDATD
Kanazawa, Japan, 20th-22nd June 2007
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Jun 2007
The impact of genetic polymorphism in CYP3A5 on the pharmacokinetics of the mixed CYP3A4/5 substrates midazolam and tacrolimus assessed by clinic
ESF-UB Conference
Costa Brava, Spain, 2007
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Jun 2007
Assessing the relevance of genetic polymorphism in CYP3A5 in the kinetics of midazolam and tacrolimus: the importance of adequate study size.
ESF-UB Conference
Costa Brava, Spain, 2007
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May 2007
Prediction of in vivo drug interactions from in vitro enzyme kinetic data: time-based versus steady state simulations.
PSWC 2007
Amsterdam, Netherlands, 22nd-25th April 2007
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May 2007
Bias in estimates of metabolic constants when applying the Michaelis-Menten equation to drugs exhibiting atypical enzyme kinetics.
PSWC 2007
Amsterdam, Netherlands, 22nd-25th April 2007
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May 2007
Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time) -based enzyme inhibition.
PSWC 2007
Amsterdam, Netherlands, 22nd-25th April 2007
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May 2007
Mechanistic prediction of HIV drug-drug interactions in virtual populations from in vitro enzyme kinetic data: ritonavir and saquinavir.
International Workshop on Clinical Pharmacology of HIV Therapy
Budapest, Hungary, 16th-18th April 2007
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Oct 2006
Prediction of the oral clearance of midazolam using in vitro data from recombinantly expressed enzymes and inter system extrapolation factors.
14th North American ISSX Meeting
Rio Grande, Puerto Rico, 22nd-26th October 2006
Abstract published in:
Drug Metabolism Reviews
A71, 38(S2), 41, 2006
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Oct 2006
Prediction of the oral clearance of tolbutamimde in individuals with different CYP2C9 genotypes using in vitro enzyme kinetic data.
14th North American ISSX Meeting
Rio Grande, Puerto Rico, 22nd-26th October 2006
Abstract published in:
Drug Metabolism Reviews
A323, 38(S2), 209-210, 2006
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Sep 2006
Utility of data from recombinant expressed genetic variants of CYPs in predicting the influence of genotype on in vivo drug kinetics - the case for S-Warfarin.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A27, 46(9), 1067, 2006
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Sep 2006
Assessing the propagation of CYP2C9 polymorphism into the PK/PD of warfarin using clinical trial simulations (CTS).
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A28, 46(9), 1067, 2006
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Sep 2006
Prediction of metabolic drug clearance in pediatric subjects and its sensitivity to different models for the development of CYP enzymes.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A40, 46(9), 1070, 2006
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Sep 2006
A meta-analysis of CYP3A4 abundance in human liver: use of different standards contributes to apparent heterogeneity in reported values.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A82, 46(9), 1080, 2006
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Sep 2006
The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using PBPK modelling.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A18, 46(9), 1065, 2006
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Jun 2006
Prediction of the inhibitory effects of ketaconazole and fluconazole on midazolam and zolpidem clearance from in vitro data using physiologically-based pharmacokinetic modelling.
9th International Conference on Drug-Drug Interactions
Seattle WA, USA, 20th-21st June 2006
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Jun 2006
In-vitro stability of human recombinant cytochrome P450 enzymes.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A135, 38(1), 102, 2006
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Jun 2006
Estimation of the kinetic parameters of mechanism-based inhibition of CYP2D6 by methylenedioxymethamphetamine (MDMA) in cryopreserved human hepatocytes.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A193, 38(1), 140-141, 2006
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Jun 2006
Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine (MDMA): differences between expressed enzyme systems and human liver microsomes.
9th European ISSX Meeting
Manchester, UK, June 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A54, 38(1), 45, 2006
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Jun 2006
The use of recombinantly expressed standards for immuno-quantification of hepatic CYP3A5 can result in an underprediction of CYP3A5 abundance.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A146, 38(1), 109, 2006
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Jun 2006
Modelling of the age related changes of human CYP enzymes for predicting drug disposition in neonates, infants and children.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A84, 38(1), 20-21, 2006
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Jun 2006
Co-operativity in the in vitro kinetics of cytochrome P450 (CYP) mediated drug metabolism will have minimal impact on in vivo metabolic clearance.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A127, 38(1), 14, 2006
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Jun 2006
Predicting drug interactions with selective serotonin reuptake Inhibitors (SSRIs): impact of non-specific binding and active uptake.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A100, 38(1), 79, 2006
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Jun 2006
The propagation of genetic polymorphism in CYP2C9 into tolbutamide pharmacokinetics: assessment using an intergrated model.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A206, 38(1), 148, 2006
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Jun 2006
Prediction of non-specific hepatic microsomal binding from readily available physicochemical properties.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A231, 38(1), 162, 2006
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Jun 2006
The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using physiologically-based pharmacokinetic modelling.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A103, 38(1), 81, 2006
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Jun 2006
Differences in cytochrome P450 (CYP3A4) expression alone do not explain inter-individual variability in CYP3A mediated hepatic testosterone 6ß hydroxylase (TST6ßOH) activity.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A129, 38(1), 98, 2006
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Jun 2006
Prediction of the oral clearance of S-warfarin in CYP2C9 genotypes from in vitro enzyme kinetic data.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A121, 38(1), 92-93, 2006
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Jan 2006
Values of human hepatocellularity per gram of liver and associated variability for use in the prediction of human in vitro metabolic clearance.
HUG Meeting
Copenhagen, Denmark, 26th-27th January 2006
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Nov 2005
Simulations to assess the propagation of the impact of genetic polymorphism
in CYP enzymes into PK and PD outcomes: warfarin and dextromethorphan
as examples.
AAPS Meeting 2005
Nashville TN, USA, 6th-10th November 2005
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Jun 2005
Genetic algorithms and their applications in PK/PD data analysis.
1st PharmSciFair
Nice, France, 12th-17th June 2005
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Jun 2005
Incorporation of inter-individual variability into the prediction of in vivo
drug clearance.
1st PharmSciFair
Nice, France 12th-17th June 2005
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-
Jun 2005
The propagation of genetic polymorphism in CYP2C9 into warfarin pharmacokinetics: an integrated model.
1st PharmSciFair
Nice, France 12th-17th June 2005
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-
Jun 2005
The impact of study design on the estimation of parameters describing mechanism-based enzyme inhibition.
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
Inter-individual variability in the catalytic activity of CYP3A4 per unit of
enzyme (kcat).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
Prediction of xenobiotic clearance in humans: in vitro-in vivo extrapolation (IVIVE) vs allometric scaling (AS).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
Implications of the disparity in relative holo:apo-protein contents of different standards used for immuno-quantification of hepatic P450 3A4 (CYP3A4).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
A critical evaluation of the experimental design in reports of mechanism based inhibition (MBI) studies and the assessment of their implication for in vitro-in vivo extrapolation (IVIVE).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Apr 2005
Inter- and intra-individual variability in gastro-intestinal physiology has significant effects on the prediction of fraction of dose absorbed (fa).
3rd WCDATD
Barcelona, Spain, 18th-20th April 2005
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-
Nov 2004
Genetic algorithms and their applications in PK/PD data analysis
Pharmacokinetics UK 2004
Belfast, UK, 17th-18th November 2004
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Feb 2004
Inter and intra-individual variability in physiological parameters of gastro-intestinal tract has significant effects on the predicted fraction of dose absorbed.
LogP 2004
Zurich, Switzerland, 29th February-4th March 2004
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Feb 2004
Accounting for first pass gut metabolism improves the relationship between lipophilicity and in vivo permeability.
LogP 2004
Zurich, Switzerland, 29th February-4th March 2004
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Jun 2003
Prediction drug clearance allowing for the influence of P-glycoprotein activity using SIMCYP.
The Proceedings of the 6th Congress of European Association for Clinial Pharmacology and Therapeutics
152, June 24th-28th 2003, Istanbul
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Jun 2002
Population clearance prediction of 13 drugs using SIMCYP.
Pharmacologist
44 (Supplement 1), LB87, 2002
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Jul 2001
Prediction of fluconazole interaction with midazolam and triazolam: Incorporating population variability.
Proceedings of the British Pharmacological Society
July 3rd-5th 2001, Clinical Pharmacology Section, University College, Dublin.
Abstract published in:
British Journal of Clinical Pharmacology A26, 52(4), 484, 2001
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Jul 2001
Reference values for human microsomal protein per gram of liver.
Proceedings of the British Pharmacological Society
July 3rd-5th 2001, Clinical Pharmacology Section, University College, Dublin.
Abstract published in:
British Journal of Clinical Pharmacology A10, 52(4), 471, 2001
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Nov 2000
Incorporating interindividual variability into in vitro–in vivo extrapolation.
7th EUFEPS Conference
Optimising Drug Development: Strategies to Assess Drug Metabolism/Transport Interaction Potential – Towards a Consensus
November 13th-15th 2000, Basel, Switzerland
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Jul 1999
Incorporating variability into prediction of drug-drug interactions: moving from deterministic to a stochastic approach.
Mathematics in Medicine Initiative (MiMI), Compartmental Modelling and Pharmacokinetic Analysis
July 20th-22nd 1999, University of Warwick, United Kingdom.
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Aug 1997
Metabolic variability in populations.
In: The Population Approach: measuring and managing variability in response, concentration and dose.
ECSC-EC-EAE 9-13, Brussels, Luxembourg, 1997.
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Aug 1995
The determination of drug metabolising status in vivo: pharmacokinetic and statistical issues.
In: Advances in Drug Metabolism in Man.
(Eds. Pacifies GM & Fracchia GN)
ECSC-EC-EAE 37-55, Brussels, Luxembourg, 1995
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Aug 1995
Phenotyping populations: pharmacokinetic and statistical issues.
In: Variability and Specificity in Drug Metabolism.
(Eds. Alvan G, Balant LP, Bechtel PR et al.)
ECSC-EC-EAE 191-203, Brussels, Luxembourg, 1995
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Aug 1990
Pharmacokinetic-pharmacogenetic modeling – a basis for the display and detection of polymorphisms in drug metabolism.
In: Proceedings of European Consensus Conference on Pharmacogenetics.
(Eds. Alvan G et al.)
ECSC-EC-EAE 59-67 Brussels, Luxembourg, 1990
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Aug 1990
Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism – statistical methods.
In: Proceedings of European Consensus Conference on Pharmacogenetics.
(Eds. Alvan G et al.)
ECSC-EC-EAE 43-52, Brussels, Luxembourg, 1990