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Nov 2012
Application of Simcyp to simulate PK as well as response of nifedipine in Japanese and Caucasian populations.
27th JSSX Annual Meeting
Tokyo, Japan, November 20-22, 2012
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Oct 2012
Physiologically based PK/PD modelling to predict ibuprofen exposure response in paediatrics.
14th VKliPha Annual Conference
Rostock, Germany, October 14-20, 2012
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Oct 2012
A dynamic physiologically-based pharmacokinetic (PBPK) model to predict the disposition of
rosuvastatin in human and the extent of drug-drug interactions.
AAPS Annual Meeting 2012
Chicago IL, USA, October 14-18, 2012
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Oct 2012
The rat as a model for screening intestinal metabolism potential.
AAPS Annual Meeting 2012
Chicago IL, USA, October 14-18, 2012
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Oct 2012
Development of a minimal-PBPK model for simulating monoclonal antibody pharmacokinetics in humans.
AAPS Annual Meeting 2012
Chicago IL, USA, October 14-18, 2012
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Oct 2012
Mechanistic deconvolution using the ADAM model: Part 1. Establishing mechanistic IVIVC for controlled release formulations of the high extraction BCS Class I drug metoprolol: comparison with conventional IVIVC models.
AAPS Annual Meeting 2012
Chicago IL, USA, October 14-18, 2012
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Oct 2012
Mechanistic Deconvolution Using the ADAM Model: Part 2. Designing a new once daily formulation for metoprolol based on mechanistic IVIVC and studying the population variability in its pharmacokinetics.
AAPS Annual Meeting 2012
Chicago IL, USA, October 14-18, 2012
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Oct 2012
Quantitative prediction of formulation-specific food effects for BCS/BDDCS Class II drug Nifedipine and population variability of its pharmacokinetics using the ADAM model within the Simcyp Simulator.
AAPS Annual Meeting 2012
Chicago IL, USA, October 14-18, 2012
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Sep 2012
Mapping in vitro and in vivo derived CYP3A ontogeny function: a critical comparison between various ontogeny models.
ACCP Annual Meeting 2012
San Diego CA, USA, September 23-25, 2012
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Sep 2012
Development and application of a mechanistic physiologically based pharmacokinetic model to assess oral drug availability post bariatric surgery in morbidly obese patients.
ACCP Annual Meeting 2012
San Diego CA, USA, September 23-25, 2012
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Sep 2012
A comparison of single species allometric methods for the prediction of renal clearance in man.
13th Annual Simcyp Consortium Meeting
Sheffield, UK, September 17-19, 2012
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Sep 2012
Quantitative prediction of formulation-specific food effects for BCS/BDDCS Class II drug nifedipine and population variability of its pharmacokinetics using the ADAM model within the Simcyp Simulator.
13th Annual Simcyp Consortium Meeting
Sheffield, UK, September 17-19, 2012
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Sep 2012
A critical comparison between CYP1A2 and 3A4 ontogeny profiles used in pediatric PBPK models.
1st World Conference of Pharmacometrics
Seoul, Korea, September 5-7, 2012
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Sep 2012
PBPK/PD approach to discern potential sex and ethnic differences in the time course of QT prolongation following quinidine administration: Caucasian vs Korean healthy populations.
1st World Conference of Pharmacometrics
Seoul, Korea, September 5-7, 2012
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Sep 2012
Top-down modeling meets bottom-up modeling: the physiological and physicochemical basis for the ontogeny of UGT2B7-mediated drug glucuronidation.
1st World Conference of Pharmacometrics
Seoul, Korea, September 5-7, 2012
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Sep 2012
Application of the target-mediated drug disposition approach within a minimal PBPK model to investigate pharmacokinetics of therapeutic proteins.
1st World Conference of Pharmacometrics
Seoul, Korea, September 5-7, 2012
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Sep 2012
Application of a PBPK/PD model describing the change in systolic blood pressure following administration of immediate release and controlled release nifedipine formulations.
1st World Conference of Pharmacometrics
Seoul, Korea, September 5-7, 2012
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Jul 2012
Simulation of the effect of urine pH on renal drug clearance using a novel population based mechanistic kidney model (Mech KiM).
Gordon Research Conference – Drug Metabolism
Holderness NH, USA, July 8-13, 2012
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Jun 2012
What is the contribution of CYP2B6 to bupropion metabolic clearance? Implications for the prediction of CYP2B6 mediated drug-drug interactions.
19th MDO/12th European ISSX Meeting
Noordwijk aan Zee, Netherlands, June 17-21, 2012
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Jun 2012
Mapping in vitro and in vivo derived CYP3A ontogeny function: a critical comparison between various ontogeny models.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
Prediction of the hypnotic effects of zolpidem by extrapolation of a mechanism-based PKPD model developed for triazolam in healthy volunteers.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
Model-based prediction of domperidone and ketoconazole interaction and its impact on QTc proglongation.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
A systems approach to predicting differences in pharmacological response to a CYP1A2 substrate, resulting from pharmacokinetic differences in non-smokers, passive smokers and heavy smokers.
<21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
Predicting the developmental PK/PD of cyclosporine (CsA) in paediatrics.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
Development and application of a mechanistic physiologically based pharmacokinetic model to assess oral drug availability post bariatric surgery in morbidly obese patients.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
Application of the Simcyp PBPK/PD model to simulate PK and PD of nifedipine in Japanese populations.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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Jun 2012
Prediction of serum and certebrospinal fluid concentrations of carbamazepine: an application of parameter estimation and the permeability limited 4-compartment brain model in Simcyp.
21st PAGE Meeting
Venice, Italy, June 5-8, 2012
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May 2012
Development of a minimal-PBPK model for simulating monclonal antibody pharmacokinetics in human.
AAPS National Biotechnology Conference
San Diego CA, USA, May 21-23, 2012
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Mar 2012
Population-based mechanistic modelling of absorption of the BCS/BDDCS Class II drug nifedipine: quantitative prediction of formulation-specific food effects.
8th PBP World Meeting
Istanbul, Turkey, March 19-22, 2012
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Mar 2012
Assessment of the induction of systemic clearance versus first-pass effect of midazolam (MDZ) using a physiologically-based dynamic model.
113th ASCPT Meeting
National Harbor MD, USA, March 14-17, 2012
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Mar 2012
Pharmacokinetic and pharmacodynamic analysis of efavirenz dose reduction using a physiologically-based dynamic model.
113th ASCPT Meeting
National Harbor MD, USA, March 14-17, 2012
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Mar 2012
Prediction of the Impact of P-gp-Mediated Efflux on the Dose Proportionality of Digoxin Bioavailability.
113th ASCPT Meeting
National Harbor MD, USA, March 14-17, 2012
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