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Nov 2011
A user-friendly physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain.
26th JSSX Annual Meeting
Hiroshima, Japan, 16th-18th November 2011
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Nov 2011
Predicting the effect of CYP2D6 polymorphism on pharmacodynamic response to metoprolol.
PKUK 2011
Durham, UK, 9th-11th November 2011
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Oct 2011
Development and application of an in silico pharmacokinetic 'post bariatric surgery model' in a morbidly obese population to assess drug absorption and metabolism from the gastrointestinal tract.
AAPS Annual Meeting
Washington DC, USA, 23rd-27th October 2011
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Oct 2011
A mechanistic model for the prediction of human-equilibrium blood-to-plasma concentration ratio (B/P): basic and neutraL drugs.
AAPS Annual Meeting
Washington DC, USA, 23rd-27th October 2011
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Oct 2011
A performance evaluation of Simcyp Dog - a fully mechanistic physiologically-based pharmacokinetic dog model - based upon a variety of celecoxib IV and oral formulations.
AAPS Annual Meeting
Washington DC, USA, 23rd-27th October 2011
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Oct 2011
P-gp efflux has no impact on dose proportionality of digoxin bioavailability over a dose range of 0.125 to 1.5 mg: the outcome of a new PBPK model, that includes the in vitro transporter information, is consistent with the clinical observations.
Annual Congress for Clinical Pharmacology
Zurich, Switzerland, 20th-22nd October 2011
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Oct 2011
An investigation into the prediction of in vivo clearance for a range of aldehyde oxidase substrates using a mechanistic population-based pharmacokinetic model.
17th North American ISSX Meeting
Atlanta GA, USA 16th-20th October 2011
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Aug 2011
A performance evaluation of Simcyp Dog - a full mechanistic physiologically based pharmacokinetic dog model - based upon a variety of theophylline IV and oral formulations.
8th World Congress on Alternative & Animal Use in the Life Sciences
Montreal, Canada, 21st-25th August 2011
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Jun 2011
Prediction of diclofenac pharmacokinetics using earl drug discovery in vitro data in a mechanistic dog physiologicallybased pharmacokinetic model - 'Simcyp Dog'.
3rd Pharm Sci Fair
Prague, Czech Republic, 13th-17th June 2011
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Jun 2011
Sources of inter-individual variability in IVIVE of clearance. An investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model.
3rd Pharm Sci Fair
Prague, Czech Republic, 13th-17th June 2011
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Jun 2011
A physiologically-based pharmacokinetic (PBPK) brain model and its application in simulating drug disposition in brain.
PAGE Meeting 2011
Athens, Greece, 7th-10th June 2011
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May 2011
Predicting the effect of interlukin-6, an inflammatory cytokine, on time-dependent reduction of cyclosporine clearance: an application of the Simcyp Population-Based Simulator to suppression of CYP450 by biologics.
AAPS National Biotechnology Conference
San Francisco CL, USA, 16th-18th May 2011
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Apr 2011
Prediction of differences in pharmacokinetics between Chinese and Caucasian populations using a mechanistic physiologically-based pharmacokinetic model.
4th Asia Pacific ISSX Meeting
Tainan City, Taiwan, 22nd-26th April 2011
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Apr 2011
Modelling the effect of interleukin-6, an inflammatory cytokine, on time-dependent reduction of cyclosporine clearance: an application of the Simcyp Population-based Simulator to suppression of CYP450 by biologics.
ACoP 2011 Meeting
San Diego CA, USA, 3rd-7th April 2011
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Apr 2011
Combining in vitro-in-vivo extrapolation (IVIVE) and physiologically-based pharmacokinetics (PBPK) with drug related risk assessment: putting pieces together for a priori assessment of the likelihood of cardiotoxicity.
ACoP 2011 Meeting
San Diego CA, USA, 3rd-7th April 2011
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Mar 2011
Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "advanced dissolution, absorption, metabolism (ADAM)" model.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
Physiologically-based pharmacokinetics (PBPK) with and without diffusion limited permeability: modelling drug concentration-time profile in brain.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
Interplay of transport and metabolism in the gut: predictions of drug-drug interactions using physiologically based pharmacokinetic modelling.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
Prediction of OAPP1B1-mediated drug-drug interaction between repaglinide and cyclosporine using physiologically based pharmacokinetic (PBPK) modelling.
AAPS Workshop
Bethesda MD, USA, 14th-16th March 2011
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Mar 2011
A bottom-up approach to predicting the pharmacokinetics (PK) of theophylline (theo) and its interaction with fluvoxamine (fluv) in liver cirrhosis.
112th ASCPT Meeting
Dallas TX, USA, 2nd-5th March 2011
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Mar 2011
Prediction of the increase in systematic exposure of paroxetine in patients with renal impairment.
112th ASCPT Meeting
Dallas TX, USA, 2nd-5th March 2011
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Feb 2011
Drug clearance in obese patients: shall we expect variations?
National Obesity Forum, Northwest Chapter Obesity Training Day
Salford, UK, 1st February 2011
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