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Oct 2006
Prediction of the oral clearance of midazolam using in vitro data from recombinantly expressed enzymes and inter system extrapolation factors.
14th North American ISSX Meeting
Rio Grande, Puerto Rico, 22nd-26th October 2006
Abstract published in:
Drug Metabolism Reviews
A71, 38(S2), 41, 2006
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Oct 2006
Prediction of the oral clearance of tolbutamimde in individuals with different CYP2C9 genotypes using in vitro enzyme kinetic data.
14th North American ISSX Meeting
Rio Grande, Puerto Rico, 22nd-26th October 2006
Abstract published in:
Drug Metabolism Reviews
A323, 38(S2), 209-210, 2006
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Sep 2006
Utility of data from recombinant expressed genetic variants of CYPs in predicting the influence of genotype on in vivo drug kinetics - the case for S-Warfarin.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A27, 46(9), 1067, 2006
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Sep 2006
Assessing the propagation of CYP2C9 polymorphism into the PK/PD of warfarin using clinical trial simulations (CTS).
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A28, 46(9), 1067, 2006
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Sep 2006
Prediction of metabolic drug clearance in pediatric subjects and its sensitivity to different models for the development of CYP enzymes.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A40, 46(9), 1070, 2006
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Sep 2006
A meta-analysis of CYP3A4 abundance in human liver: use of different standards contributes to apparent heterogeneity in reported values.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A82, 46(9), 1080, 2006
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Sep 2006
The impact of ketoconazole (KTZ) dosage regimen on midazolam clearance and its prediction using PBPK modelling.
35th ACCP Meeting
Cambridge MA, USA, 17th-19th September 2006
Abstract published in:
Journal of Clinical Pharmacology
A18, 46(9), 1065, 2006
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Jun 2006
Prediction of the inhibitory effects of ketaconazole and fluconazole on midazolam and zolpidem clearance from in vitro data using physiologically-based pharmacokinetic modelling.
9th International Conference on Drug-Drug Interactions
Seattle WA, USA, 20th-21st June 2006
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Jun 2006
In-vitro stability of human recombinant cytochrome P450 enzymes.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A135, 38(1), 102, 2006
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Jun 2006
Estimation of the kinetic parameters of mechanism-based inhibition of CYP2D6 by methylenedioxymethamphetamine (MDMA) in cryopreserved human hepatocytes.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A193, 38(1), 140-141, 2006
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Jun 2006
Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine (MDMA): differences between expressed enzyme systems and human liver microsomes.
9th European ISSX Meeting
Manchester, UK, June 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A54, 38(1), 45, 2006
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Jun 2006
The use of recombinantly expressed standards for immuno-quantification of hepatic CYP3A5 can result in an underprediction of CYP3A5 abundance.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A146, 38(1), 109, 2006
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Jun 2006
Modelling of the age related changes of human CYP enzymes for predicting drug disposition in neonates, infants and children.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A84, 38(1), 20-21, 2006
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Jun 2006
Co-operativity in the in vitro kinetics of cytochrome P450 (CYP) mediated drug metabolism will have minimal impact on in vivo metabolic clearance.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A127, 38(1), 14, 2006
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Jun 2006
Predicting drug interactions with selective serotonin reuptake Inhibitors (SSRIs): impact of non-specific binding and active uptake.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A100, 38(1), 79, 2006
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Jun 2006
The propagation of genetic polymorphism in CYP2C9 into tolbutamide pharmacokinetics: assessment using an intergrated model.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A206, 38(1), 148, 2006
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Jun 2006
Prediction of non-specific hepatic microsomal binding from readily available physicochemical properties.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A231, 38(1), 162, 2006
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Jun 2006
The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using physiologically-based pharmacokinetic modelling.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A103, 38(1), 81, 2006
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Jun 2006
Differences in cytochrome P450 (CYP3A4) expression alone do not explain inter-individual variability in CYP3A mediated hepatic testosterone 6ß hydroxylase (TST6ßOH) activity.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A129, 38(1), 98, 2006
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Jun 2006
Prediction of the oral clearance of S-warfarin in CYP2C9 genotypes from in vitro enzyme kinetic data.
9th European ISSX Meeting
Manchester, UK, 4th-7th June 2006
Abstract published in:
Drug Metabolism Reviews
A121, 38(1), 92-93, 2006
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Jan 2006
Values of human hepatocellularity per gram of liver and associated variability for use in the prediction of human in vitro metabolic clearance.
HUG Meeting
Copenhagen, Denmark, 26th-27th January 2006
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