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Barter ZE, Tucker GT, Rostami-Hodjegan A, Rowland-Yeo K & Howgate EM
Oct 2006
Prediction of the oral clearance of midazolam using in vitro data from recombinantly expressed enzymes and inter system extrapolation factors.
Abstract published in:
Drug Metabolism Reviews A71, 38(S2), 41, 2006.
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Almond LM, Rowland-Yeo K, Dickinson GL, Howgate EM, Tucker GT & Rostami-Hodjegan A
Oct 2006
Prediction of the oral clearance of tolbutamimde in individuals with different CYP2C9 genotypes using in vitro enzyme kinetic data.
14th North American ISSX Meeting
October 22nd-26th 2006, Rio Grande, Puerto Rico.
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Almond LM, Rowland-Yeo K, Howgate EM, Tucker GT & Rostami-Hodjegan A
Sep 2006
Utility of data from recombinant expressed genetic variants of CYPs in predicting the influence of genotype on in vivo drug kinetics - the case for S-Warfarin.
35th Annual Meeting of American College of Clinical Pharmacology
September 17th-19th 2006, Cambridge, Massachusetts.
Abstract published in:
Journal of Clinical Pharmacology A27, 46(9), 1067, 2006.
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Dickinson GL, Lennard MS, Tucker GT & Rostami-Hodjegan A
Sep 2006
Assessing the propagation of CYP2C9 polymorphism into the PK/PD of warfarin using clinical trial simulations (CTS).
35th Annual Meeting of American College of Clinical Pharmacology
September 17th-19th 2006, Cambridge, Massachusetts.
Abstract published in:
Journal of Clinical Pharmacology A28, 46(9), 1067, 2006.
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Johnson TN, Tucker GT & Rostami-Hodjegan A
Sep 2006
Prediction of metabolic drug clearance in pediatric subjects and its sensitivity to different models for the development of CYP enzymes.
35th Annual Meeting of American College of Clinical Pharmacology
September 17th-19th 2006, Cambridge, Massachusetts.
Abstract published in:
Journal of Clinical Pharmacology A40, 46(9), 1070, 2006.
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Barter ZE, Rowland-Yeo K, Tucker GT & Rostami-Hodjegan A
Sep 2006
A meta-analysis of CYP3A4 abundance in human liver: use of different standards contributes to apparent heterogeneity in reported values.
35th Annual Meeting of American College of Clinical Pharmacology
September 17th-19th 2006, Cambridge, Massachusetts.
Abstract published in:
Journal of Clinical Pharmacology A82, 46(9), 1080, 2006.
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Ozdemir M, Crewe KH, Tucker GT & Rostami-Hodjegan A
Sep 2006
The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using PBPK modelling.
35th Annual Meeting of American College of Clinical Pharmacology
September 17th-19th 2006, Cambridge, Massachusetts.
Abstract published in:
Journal of Clinical Pharmacology A18, 46(9), 1065, 2006.
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Rowland-Yeo K, Jamei M, Yang J, Tucker GT & Rostami-Hodjegan A
Jun 2006
Prediction of the inhibitory effects of ketaconazole and fluconazole on midazolam and zolpidem clearance from in vitro data using physiologically-based pharmacokinetic modelling.
In Vitro Stability of Human Recombinant Cytochrome P450 Enzymes
9th International Conference on Drug-Drug Interactions
June 20th-21st 2006, Seattle, WA, USA.
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Yang J, Tucker GT, & Rostami-Hodjegan A
Jun 2006
In-vitro stability of human recombinant cytochrome P450 enzymes.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Van LM, Hammond C, Swales J, Wilson C, Rostami-Hodjegan A & Hargreaves JA
Jun 2006
Estimation of the kinetic parameters of mechanism-based inhibition of CYP2D6 by methylenedioxymethamphetamine (MDMA) in cryopreserved human hepatocytes.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Van LM, Rowland-Yeo K, Lennard MS, Tucker GT & Rostami-Hodjegan A
Jun 2006
Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine (MDMA): differences between expressed enzyme systems and human liver microsomes.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Perrett HF, Barter ZE, Edwards RJ, Lennard MS, Rostami-Hodjegan A & Tucker GT
Jun 2006
The use of recombinantly expressed standards for immuno-quantification of hepatic CYP3A5 can result in an underprediction of CYP3A5 abundance.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Johnson TN, Tucker GT & Rostami-Hodjegan A
Jun 2006
Modelling of the age related changes of human CYP enzymes for predicting drug disposition in neonates, infants and children.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Jamei M, Rostami-Hodjegan A & Tucker GT
Jun 2006
Co-operativity in the in vitro kinetics of cytochrome P450 (CYP) mediated drug metabolism will have minimal impact on in vivo metabolic clearance.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Heydari A, Rowland-Yeo K, Lennard MS, Tucker GT & Rostami-Hodjegan A
Jun 2006
Predicting drug interactions with selective serotonin reuptake Inhibitors (SSRIs): impact of non-specific binding and active uptake.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Dickinson GL, Lennard MS, Tucker GT & Rostami-Hodjegan A
Jun 2006
The propagation of genetic polymorphism in CYP2C9 into tolbutamide pharmacokinetics: assessment using an intergrated model.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Turner DB, Rostami-Hodjegan A, Tucker GT & Rowland-Yeo K
Jun 2006
Prediction of non-specific hepatic microsomal binding from readily available physicochemical properties.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Ozdemir M, Crewe HK, Tucker GT & Rostami-Hodjegan A
Jun 2006
The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using physiologically-based pharmacokinetic modelling.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Barter ZE, Crewe KH, Harlow JR, Lei Y, Tucker GT & Rostami-Hodjegan A
Jun 2006
Differences in cytochrome P450 (CYP3A4) expression alone do not explain inter-individual variability in CYP3A mediated hepatic testosterone 6ß hydroxylase (TST6ßOH) activity.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Almond LM, Rowland-Yeo K, Howgate EM, Tucker GT & Rostami-Hodjegan A
Jun 2006
Prediction of the oral clearance of S-warfarin in CYP2C9 genotypes from in vitro enzyme kinetic data.
9th European ISSX Meeting
June 4th-7th 2006, Manchester, UK.
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Barter ZE, Burns JL, Tucker GT & Rostami-Hodjegan A
Jan 2006
Values of human hepatocellularity per gram of liver and associated variability for use in the prediction of human in vitro metabolic clearance.
Hepatocyte User Group (HUG) Meeting
January 26th-27th 2006, Copenhagen, Denmark.
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