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Dickinson GL, Lennard MS, Tucker GT & Rostami-Hodjegan A
Nov 2005
Simulations to assess the propagation of the impact of genetic polymorphism
in CYP enzymes into PK and PD outcomes: warfarin and dextromethorphan
as examples.
AAPS Annual Meeting & Exposition
November 6th-10th 2005, Nashville, Tennessee, USA.
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Jamei M, Yang J, Rostami-Hodjegan A & Tucker GT
Jun 2005
Genetic algorithms and their applications in PK/PD data analysis. Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Howgate EM, Rowland-Yeo K, Proctor NJ, Rostami-Hodjegan A
Jun 2005
Incorporation of inter-individual variability into the prediction of in vivo
drug clearance.
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Dickinson GL, Lennard MS, Tucker GT & Rostami-Hodjegan A
Jun 2005
The propagation of genetic polymorphism in CYP2C9 into warfarin pharmacokinetics: an integrated model.
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Heydari A, Rowland-Yeo K, Lennard MS, Tucker GT & Rostami-Hodjegan A
Jun 2005
The impact of study design on the estimation of parameters describing mechanism-based enzyme inhibition.
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Lei Y, Wilson ZE, Crewe KH, Tucker GT & Rostami-Hodjegan A
Jun 2005
Inter-individual variability in the catalytic activity of CYP3A4 per unit of
enzyme (kcat).
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Shiran MR, Proctor NJ, Howgate EM, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A
Jun 2005
Prediction of xenobiotic clearance in humans: in vitro-in vivo extrapolation (IVIVE) vs allometric scaling (AS).
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Wilson ZE, Ellis SW, Edwards RJ, Tucker GT & Rostami-Hodjegan A
Jun 2005
Implications of the disparity in relative holo:apo-protein contents of different standards used for immuno-quantification of hepatic P450 3A4 (CYP3A4).
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
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Ghanbari F, Rowland-Yeo K, Tucker GT & Rostami-Hodjegan A
Jun 2005
A critical evaluation of the experimental design in reports of mechanism based inhibition (MBI) studies and the assessment of their implication for in vitro-in vivo extrapolation (IVIVE).
Pharmaceutical Sciences Fair & Exhibition
June 12th-17th 2005, Nice, France.
Available to Members only, click to login.
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Jamei M, Yang J, Rostami-Hodjegan A, & Tucker GT
Apr 2005
Inter- and intra-individual variability in gastro-intestinal physiology has significant effects on the prediction of fraction of dose absorbed (fa).
3rd World Conference on Drug Absorption, Transport & Delivery April 18th-20th 2005, Barcelona, Spain.
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