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Nov 2005
Simulations to assess the propagation of the impact of genetic polymorphism
in CYP enzymes into PK and PD outcomes: warfarin and dextromethorphan
as examples.
AAPS Meeting 2005
Nashville TN, USA, 6th-10th November 2005
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Jun 2005
Genetic algorithms and their applications in PK/PD data analysis.
1st PharmSciFair
Nice, France, 12th-17th June 2005
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Jun 2005
Incorporation of inter-individual variability into the prediction of in vivo
drug clearance.
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
The propagation of genetic polymorphism in CYP2C9 into warfarin pharmacokinetics: an integrated model.
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
The impact of study design on the estimation of parameters describing mechanism-based enzyme inhibition.
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
Inter-individual variability in the catalytic activity of CYP3A4 per unit of
enzyme (kcat).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
Prediction of xenobiotic clearance in humans: in vitro-in vivo extrapolation (IVIVE) vs allometric scaling (AS).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
Implications of the disparity in relative holo:apo-protein contents of different standards used for immuno-quantification of hepatic P450 3A4 (CYP3A4).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Jun 2005
A critical evaluation of the experimental design in reports of mechanism based inhibition (MBI) studies and the assessment of their implication for in vitro-in vivo extrapolation (IVIVE).
1st PharmSciFair
Nice, France 12th-17th June 2005
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Apr 2005
Inter- and intra-individual variability in gastro-intestinal physiology has significant effects on the prediction of fraction of dose absorbed (fa).
3rd WCDATD
Barcelona, Spain, 18th-20th April 2005
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