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Jun 2008
Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions.
Current Drug Metabolism
9 (5), 384-394, June 2008.
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Apr 2008
Metabolism of dextrorphan by CYP2D6 in different recombinantly expressed systems and its implications for the in vitro assessment of dextromethorphan metabolism.
European Journal of Pharmaceutical Sciences
E-Publication (ahead of print), 2008.
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Oct 2007
Disparity in holoprotein/apoprotein ratios of different standards
used for immunoquantification of hepatic cytochrome P450
enzymes.
Drug Metabolism & Disposition
35(10), 1733-1736, October 2007.
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Oct 2007
Prediction of intestinal first-pass drug metabolism.
Current Drug Metabolism
8(7), 676-684, October 2007.
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Jun 2007
Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time)-based enzyme inhibition.
European Journal of Pharmaceutical Sciences
31(3-4), 232-241, July 2007.
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May 2007
Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems.
European Journal of Pharmaceutical Sciences
32(1), 8-16, September 2007.
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Mar 2007
Misuse of the well-stirred model of hepatic drug clearance.
Drug Metabolism & Disposition
35(3), 501-502, March 2007.
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Feb 2007
Kinetics of the time-dependent inactivation of CYP2D6 in cryopreserved human hepatocytes by methylenedioxymethamphetamine (MDMA).
European Journal of Pharmaceutical Sciences
31(1), 53-61, May 2007.
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Jan 2007
The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies - CYP2C9 and warfarin as an example.
British Journal of Clinical Pharmacology
64(1), 14-26, July 2007.
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Jan 2007
Simulation and prediction of in vivo metabolic drug clearance from in vitro data.
Nature Reviews
6(2), 140-149, February 2007.
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Jan 2007
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
Current Drug Metabolism
8(1), 33-45, January 2007.
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Jan 2007
Incorporating in vitro information on drug metabolism into clinical trial simulations to assess the effect of CYP2D6 polymorphisms on pharmacokinetics and pharmacodynamics: dextromethorphan as a model application.
Journal of Clinical Pharmacology
47(2), 175-186, February 2007.
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Dec 2006
Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data.
Journal of Pharmaceutical Sciences
95(12), 2778-2787, December 2006.
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Nov 2006
Prediction of clearance of eleven drugs and associated variability in neonates, infants and children.
Clinical Pharmacokinetics
45(9), 931-956, September 2006.
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Nov 2006
Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.
Journal of Psychopharmacology
20(6), 842-849, November 2006.
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Nov 2006
The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).
Journal of Psychopharmacology
20(6), 834-841, November 2006.
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Jul 2006
Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling.
Xenobiotica
36(7), 567-580, July 2006.
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Jun 2006
Prediction of in vivo drug clearance from in vitro data.
I: Impact of inter-individual variability.
Xenobiotica
36(6), 473-497, June 2006.
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Jun 2006
Prediction of in vivo drug clearance from in vitro data.
II: Potential inter-ethnic differences.
Xenobiotica
36(6), 499-513, June 2006.
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Apr 2006
A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation.
Current Drug Metabolism
7(3), 315-334, April 2006.
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Dec 2005
Changes in liver volume from birth to adulthood: a meta analysis.
Liver Transplantation
12(11), 1481-1493, December 2005.
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Nov 2005
Kinetic values for mechanism-based enzyme inhibition: assessing the bias introduced by the conventional experimental protocol.
European Journal of Pharmaceutical Sciences
26(3-4), 334-340, November 2005.
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Jun 2005
Modelling approaches to dose estimation in children.
British Journal of Clinical Pharmacology
59(6), 663-669, June 2005.
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Dec 2004
Prediction of drug clearance from in vitro data for 10 drugs in neonates, infants and children using Simcyp.
Drug Metabolism Reviews
A680, 36(Supplement 1), 340, December 2004.
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Dec 2004
Predicting the clearance of CYP2C9 substrates.
Drug Metabolism & Disposition
32(12),1522 (author reply 1523), December 2004.
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Dec 2004
In silico simulations to assess the in vivo consequences of in vitro metabolic drug-drug interactions.
Drug Discovery Today: Technologies
1(4), 441-448, December 2004.
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Dec 2004
Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH.
Journal of Clinical Pharmacology
44(12), 1398-1404, December 2004.
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Oct 2004
Cytochrome P450 3A expression and activity in the human small intestine.
Clinical Pharmacology & Therapeutics
76(4), 391, October 2004.
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Oct 2004
Predicting drug-drug interactions: in vitro veritas?
EUFEPS 2004 - 8th European Congress of Pharmaceutical Sciences
October 17th-20th 2004, Brussels, Belgium.
Abstract published in:
European Journal of Pharmaceutical Sciences
SS5-3, 23(Supplement 1), 13, October 2004.
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Jul 2004
Pharmacogenetics - expectations and reality.
British Medical Journal
329(7456), 4-6, July 2004.
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May 2004
Prediction of drug clearance and its variability in neonates, infants and
children using Simcyp.
European Society for Developmental, Perinatal and Paediatric
Pharmacology, 9th Congress
June 16th-19th 2004, Marburg, Germany.
Abstract published in:
Paediatric and Perinatal Drug Therapy
L23, 6(1), 51, May 2004.
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May 2004
A comparison of methods to predict drug clearance in neonates,
infants and children.
Proceedings of the British Pharmacological Society
December 16th-18th 2003, GKT School of Biomedical Sciences,
King’s College London, Guy’s Campus.
Abstract published in:
British Journal of Clinical Pharmacology
A23, 57(5), 677-678, May 2004.
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Feb 2004
Prediction of clearance from recombinantly expressed CYPs: Intersystem extrapolation factor (ISEF).
Xenobiotica
34(2), 151-178, February 2004.
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Dec 2003
Abundance of cytochromes P450 in human liver: a meta-analysis.
British Pharmacological Society Winter Meeting
University of London, December 2003.
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Dec 2003
Reference values for the amount of microsomal protein and number of hepatocytes per gram of human liver.
Drug Metabolism Reviews
A200, 35(Supplement 1), 100, April 2003.
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Dec 2003
Sources of variability associated with quantitative predictions of drug clearance from recombinant CYP enzymes.
Drug Metabolism Reviews
A202, 35(Supplement 1), 101, April 2003.
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Oct 2003
The effects of dose staggering on metabolic drug-drug interactions.
European Journal of Pharmaceutical Sciences
20(2), 223-232, October 2003.
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Apr 2003
ISEF: an intersystem extrapolation factor for use with recombinant cytochrome P450 expressed systems.
Proceedings of the British Pharmacological Society
January 7th-10th 2003, William Harvey Research Institute, Bart’s and the London, Queen Mary’s School of Medicine and Dentistry.
Abstract published in:
British Journal of Clinical Pharmacology
A35, 55(4), 437-438, April 2003.
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Apr 2003
Determining values for human microsomal protein per gram of liver.
Proceedings of the British Pharmacological Society
January 7th-10th 2003, William Harvey Research Institute, Bart’s and the London, Queen Mary’s School of Medicine and Dentistry.
Abstract published in:
British Journal of Clinical Pharmacology
A2, 55(4), 418-419, April 2003.
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Apr 2003
Prediction of age related changes in midazolam clearance in children
using SIMCYP.
Proceedings of the British Pharmacological Society
January 7th-10th 2003, William Harvey Research Institute, Bart’s and the London, Queen Mary’s School of Medicine and Dentistry.
Abstract published in:
British Journal of Clinical Pharmacology
A26, 55(4), 432-433, April 2003.
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Apr 2003
In vitro prediction of population in vivo drug clearance using updated
scaling factors.
Proceedings of the British Pharmacological Society
January 7th-10th 2003, William Harvey Research Institute, Bart’s and the London, Queen Mary’s School of Medicine and Dentistry.
Abstract published in:
British Journal of Clinical Pharmacology
A49, 55(4), 445, April 2003.
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Dec 1999
Acute inhibition of methadone metabolism by ritonavir: projection of interaindividual variability from in vitro data.
British Journal of Clinical Pharmacology
48, 883-884, 1999.
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Jun 1999
In vivo indices of enzyme activity-the effect of renal impairment on the assessment of CYP2D6 activity.
Pharmacogenetics
9(3), 277-286, June 1999.
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Jun 1999
In vivo indices of enzyme activity-the effect of renal impairment on the assessment of CYP2D6 activity.
British Journal of Clinical Pharmacology
47, 577-578, 1999.
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Dec 1998
The determination of drug metabolising enzyme activity in vivo: pharmacokinetics and statistical issues.
Xenobiotica
28(12), 1255-1273, December 1998.
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Dec 1996
Caffeine metabolic ratios as markers of enzyme activity: a theoretical assessment.
Pharmacogenetics
6(2), 121-49, April 1996.
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