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population based pharmacokinetic modelling and simulation

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Papers

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Please view our latest papers below:


  • Barter ZE et al.

    Nov 2010

    Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations.
    Biopharmaceutics & Drug Disposition
    31, 516-532, November 2010

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  • Darwich AS et al.

    Nov 2010

    Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.
    Current Drug Metabolism
    11, 716-729, November 2010

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  • Bois FY et al.

    Jun 2010

    PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.
    Toxicology
    106, 154-161, June 2010

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  • Rowland-Yeo K et al.

    Mar 2010

    Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on the time-course of exposure to triazolam.
    European Journal of Pharmaceutical Sciences
    39, 298-309, March 2010

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  • Johnson TN et al.

    Mar 2010

    A semi-mechanistic model to predict the effects of liver cirrhosis on drug clearance.
    Clinical Pharmacokinetics
    49, 189-206, March 2010

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