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population based pharmacokinetic modelling and simulation

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Princeton, NJ

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Start Date: 06 May 2013

End Date: 10 May 2013

Intensive course:

Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD'

This event runs from 6th – 10th May 2013 at the Nassau Inn, Princeton, New Jersey, USA. 

Delegates will learn how to simulate:

• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)

Click here to download the workshop flyer.

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For further information on any of Simcyp's events please contact Kelly Turton.

Consortium members and associates include: