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Sheffield, UK
Start Date: 10 Sep 2012
End Date: 14 Sep 2012
** Registration is now closed **
Full Simcyp workshops:
‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling of PK-PD'
Delegates will learn how to simulate:
- Metabolic drug clearance (CL)
- Metabolic drug-drug interactions (DDIs)
- Gut first-pass metabolism
- Oral drug absorption incorporating food effects and the impact of dosage form
- Effect of transporters and enterohepatic recirculation on kinetics and DDIs
- Drug distribution to different organs
- Population variability in drug concentration-time profiles
Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
- Pharmacodynamic effects of different compounds
- Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)
The workshops are split into two sessions and delegates may register for all or part of the course as follows:
Part I: 10th - 12th September 2012
Part II: 12th - 14th September 2012
Click here to download the workshop flyer.