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Indianapolis, USA
Start Date: 11 Oct 2010
End Date: 15 Oct 2010
Intensive course:
‘Concepts and Applications of Predicting ADME, Pharmacokinetics and Population Variability’
The course is composed of lectures, delivered by leading experts in each field of ADME, interspersed with interactive workshops with practical examples demonstrating how in vitro data generated during drug development can be used to predict:
- Metabolic drug clearance (CL)
- Metabolic drug-drug interactions (DDIs)
- Gut first-pass metabolism
- Oral drug absorption incorporating food effects and the impact of dosage form
- Effect of transporters and enterohepatic recirculation on kinetics
- Drug distribution to different organs
- Population variability in drug concentration-time profiles
- Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
- Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)
The main emphasis is on using data generated in pre-clinical stages to understand the kinetic behaviour of drugs in various target populations. This informs decisions on the conduct and optimal design of clinical studies with the ultimate aim of improving the quality of submissions for regulatory approval.
The complete course runs from 11th – 15th October at the University Place Conference Center and Hotel (IUPUI), Indianapolis, IN. Delegates may also choose to register for part of the course:
Part I: 11th – 13th October 2010
Part II: 13th – 15th October 2010
Register on-line now
Download Indianapolis, October 2010, information (pdf)
Alternatively, for further information about this upcoming event please contact Kelly Turton.
Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield, S2 4SU UK
+44 (0) 114 2922321