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New Jersey, USA
Start Date: 17 May 2010
End Date: 21 May 2010
*** REGISTRATION HAS NOW CLOSED ***
Intensive course:
‘Concepts and Applications of Predicting ADME, Pharmacokinetics and Population Variability’
The course is comprised of lectures, delivered by leading experts in each field of ADME, interspersed with interactive workshops centred around practical examples demonstrating how in vitro data generated during drug development can be used to predict:
- Metabolic drug clearance (CL)
- Metabolic drug-drug interactions (DDIs)
- Gut first-pass metabolism
- Oral drug absorption incorporating food effects and the impact of dosage form
- Effect of transporters and enterohepatic recirculation on kinetics
- Drug distribution to different organs
- Population variability in drug concentration-time profiles
- Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
- Time-course of drug in plasma that fits observed clinical data (achieved using fitting modules within physiologically-based pharmacokinetics (PBPK) models combined with drug specific in vitro information)
The main emphasis is on using data generated in pre-clinical stages to understand the kinetic behaviour of drugs in various target populations. This informs decisions on the conduct and optimal design of clinical studies with the ultimate aim of improving the quality of submissions for regulatory approval.
The complete course runs from 17th – 21st May at the Nassau Inn, Princeton, NJ. Delegates may also choose to register for part of the course:
Part I: 17th – 19th May 2010
Part II: 19th – 21st May 2010
Download Princeton, May 2010, information (pdf)