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Simcyp Rat
Simcyp Rat is a whole-body physiologically-based pharmacokinetic (WBPBPK) modelling platform which allows plasma and organ concentration-time profiles in rat to be predicted from rat in vitro data.
Simcyp Rat can be used to increase confidence in in vitro - in vivo extrapolation (IVIVE) techniques. When used in conjunction with the Simcyp Population-based ADME Simulator, Simcyp Rat allows comparison of human and animal data without relying on allometric scaling which may not be a valid approach for some parameters. Based on the template of the original Simcyp Simulator (Version 8.1), Simcyp Rat has simplified, easy-to-use interfaces and well-validated models.
The model used in the Simcyp Rat module is based on the male Sprague-Dawley; however, the flexible platform allows the user to ‘build their own rat’ by changing parameters within the library.
Like the Simcyp human population simulator, Simcyp Rat contains databases of commonly used compounds. This allows researchers to validate implemented models and compare the properties of their new drugs with these reference compounds.
Simcyp Rat is available to Simcyp Consortium members and associates.