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Simcyp Paediatric Simulator
The Simcyp Paediatric Simulator allows pharmacokinetic behaviour to be modelled in infants, neonates and children. This provides valuable information relevant to first-time dosing decisions and the design of clinical studies.
The Simulator includes a full physiologically-based pharmacokinetic (PBPK) model together with extensive libraries on demographics, developmental physiology and the ontogeny of drug elimination pathways. It allows population variability in pharmacokinetics to be simulated over any age range and potential drug-drug interactions to be quantified.
Predictions can be made either from in vitro data, or from adult in vivo values by retrograde modelling.