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Simcyp Animal
Simcyp Animal currently incorporates two animal models - Simcyp Rat and Simcyp Dog. While the recent addition of Simcyp Dog has already extended the capabilities of the Simcyp Animal Simulator there is also a new Mouse Model in the late stages of development. Simulations with Simcyp Animal models can help users understand the behaviour of their drugs and have been used to increase confidence in in vitro – in vivo extrapolation (IVIVE) before moving to human simulations. In addition, Simcyp Dog can be used to help assess the likelihood of observing food effects for orally dosed drugs.
When used in conjunction with the Simcyp Population-based Simulator, Simcyp Animal allows comparison of human and animal data without relying upon allometric scaling which may not be a valid approach for some parameters. Based on the template of the original Simcyp Simulator, Simcyp Animal has simplified, easy-to-use interfaces and well-validated models. Like the Simcyp Simulator, the Animal models are provided with databases of commonly used compounds. This allows researchers to validate implemented models and compare the properties of their new drugs with these reference compounds. Also provided are the Automated Sensitivity Analysis and Batch Processor tools.
Simcyp Rat is a whole-body physiologically-based pharmacokinetic (WBPBPK) modelling platform which allows plasma and organ concentration-time profiles in rat to be predicted from rat in vitro data. The model used in the Simcyp Rat module is based on 250g male Sprague-Dawley.
Like Simcyp Rat, the Simcyp Dog is a WBPBPK modelling platform. It is based upon a 10 kg virtual Beagle dog. The model has all the features of the Simcyp Rat but with two major differences. First, there is a fully mechanistic gut permeability (MechPeff) model that accounts for i) the relative leakiness (paracellular pores) of the dog gut wall relative to human and rat; ii) explicitly accounts for unstirred boundary layer effects on permeability, and iii) considers the effective absorptive surface area of the different regions (villous morphology) of the small and large intestine and its impact upon permeability. A second major difference to Simcyp Rat is the incorporation of variability (no covariates presently) of many absorption-related parameters (luminal pH and bile salt concentrations, gastric emptying, intestinal transit time and GI villous morphology).
Simcyp Animal is available to Simcyp Consortium members and associates. For further information, please use the contact us form.