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Flinders University receives funding through Simcyp Grants and Partnership Scheme
Date: 15 May 2012
Simcyp is pleased to announce that Flinders University of Adelaide, Australia, submitted the successful bid in the 2011 round of the Simcyp Grant and Partnership Scheme. Funding has now been secured for a two year post-doctoral project to assess the potential for Simcyp-guided dosing of olanzapine, a drug which is widely used for the treatment of schizophrenia, acute mania and bipolar disorder.
Therapeutic drug monitoring for olanzapine is poorly utilised and a simple, rapid and non-invasive approach to support clinicians with individualising dose is urgently required. The team propose an approach to guide olanzapine dosing using Simcyp and the paraxanthine/caffeine 4 hour ratio in saliva (Simcyp-guided dosing). They hypothesise that a validated olanzapine profile in Simcyp can be used together with knowledge about major covariates that influence olanzapine pharmacokinetics to predict the dose required to attain steady-state concentration within the therapeutic range. This approach is highly novel and is a new and exciting application of the Simcyp platform in clinical practice.
The Principal Investigator for the project is Dr Andrew Rowland.
Over thirty applications were received in the 2011 call for the Simcyp Grants and Partnership Scheme which is open to institutions with a successful track record in the area of proposed research who hold a valid Simcyp not-for-profit license. Up to three-year’s funding for PhD studentships or two years for post-doctoral research is available. For further information on the scheme please click here.