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New review describes PBPK modelling for environmental chemicals
Date: 29 Jul 2010
A new paper, currently in press in the journal Toxicology, reviews physiologically-based pharmacokinetic modelling (PBPK) for the assessment of population variability in the absorption, distribution, metabolism and excretion (ADME) of environmental chemicals.
The article examines the state of the art on PBPK modelling of inter-individual variability, which has advanced to become a mainstream commercial activity for drug development. The authors show how the concepts and tools now available also allow for the prediction of toxicokinetics for environmental/occupational contaminants.
The sources of variability in PK are reviewed. This is followed by examples of the a priori application of modelling to chemical risk assessment and discussion on the a posterior assessment of variability using Bayesian approaches.
The paper, entitled ‘PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals’, was written by Frederic Y. Bois (from the Institut National de l’environnement industriel et des risques (Ineris)), Masoud Jamei (from Simcyp Limited) and Harvey Clewell (from the Hamner Institutes for Health Sciences).
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