home > news > 2010 > january > simcyp to host dmdg spring meeting – oral drug absorption: bridging dmpk and pharmaceutics
Simcyp to host DMDG Spring Meeting – Oral Drug Absorption: Bridging DMPK and Pharmaceutics
Date: 05 Jan 2010
Simcyp Limited is proud to be supporting the 2010 Spring Meeting of the Drug Metabolism Discussion Group. This one-day event will be held in Sheffield, UK, on Friday 5th February.
The meeting aims to explore the main aspects of oral drug absorption emphasising the need for better communication and collaboration between DMPK and pharmaceutical researchers. Oral drug absorption is a complex process involving a variety of inter-connected processes, including drug liberation (from formulation), dissolution, permeability/ transport, and metabolism. All of these can be affected by gastrointestinal physiology. The sessions will cover both optimal experimental design and the use of generated data to predict drug absorption in humans.
Confirmed speakers include:
Clive Wilson, University of Strathclyde
‘Understanding physiological variability in clinical trials’
Steve Sutton, University of New England
‘The use of gastrointestinal intubation studies for controlled release development’
Iain Haslam, AstraZeneca
‘Cross‐species Ussing chamber models for investigating permeability, transport and more’
Abdul Basit, University of London
Title tbc
Alex Galetin, University of Manchester
‘Classification system for intestinal availability and optimisation of in vitro‐in vivo extrapolation from in vitro clearance and permeability data’
Mark Seymour, Xceleron
‘Absolute bioavailability of fexofenadine: twelve years late’
Cristina Ciocca, Accelera s.r.l.
‘Oral drug delivery systems: new tools for early drug development’
Vikash Sinha, Johnson & Johnson
‘Modeling of oral nanosuspension absorption in human’
Iain Grant, AstraZeneca
‘The use of absorption modelling software to assess NCE development potential’
Kenny Watson, Pfizer
‘Applications of modelling and simulation in the prediction of oral absorption’
James Yates, AstraZeneca
‘Using physiologically based pharmacokinetic modelling and pre‐clinical data to understand absorption potential of NCEs’
Kiyohiko Sugano, Pfizer
‘Computational oral absorption simulation: Progress in 2008‐2009’
The meeting organising committee is currently calling for posters and delegate registrations from DMDG member companies. Registration closes on 18th January 2010.
DMDG delegates may also take the opportunity to attend an independent Simcyp workshop on population-based prediction of oral drug absorption on Thursday 4th February (2– 5pm). Attendees will have the opportunity to try the Advanced Dissolution Absorption and Metabolism (ADAM) model in the Simcyp Simulator and put their questions to the Simcyp team. Please note that there is no charge for this event for DMDG delegates.
For further information, please download the flyer or contact Kelly Jinkinson using the contact us form.