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PhRMA reviews industry strategies for addressing time-based inhibition
Date: 19 May 2009
A new report by members of the Pharmaceutical Research and Manufacturers of America (PhRMA) reviews the phenomenon of time-dependent inhibition (TDI) and the methods used in its assessment.
The publication follows an anonymous survey of industry strategies for TDI. The authors, representing sixteen pharmaceutical research organisations, present the survey findings and provide a consensus recommendation regarding common practices. Their discussions note the increasing utility and importance of PBPK-based approaches including modelling and simulation using Simcyp.
The paper by Scott W. Grimm et al. is entitled, ‘The conduct of in vitro studies to address time-dependent inhibition of drug metabolizing enzymes: a perspective of the Pharmaceutical Research and Manufacturers of America (PhRMA).’ It is available as an e-publication ahead of print in the journal Drug Metabolism and Disposition.
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