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Amgen study investigates herb-drug interactions due to CYP inhibition
Date: 31 Jul 2009
A paper to be published in the journal Drug Metabolism and Disposition highlights the issue of drug-drug interactions involving alternative therapies.
The aim of the study was to characterise the metabolism and drug interaction potential of six xanthone derivatives found in mangosteen, a tropical fruit used as a homeopathic therapy for a variety of disorders. In vitro experiments were performed to assess the metabolism by, and inhibition of, various CYP isoforms.
The Simcyp Population-based ADME Simulator was then used to assess in vivo plasma concentrations of α-mangostin, the most abundant xanthone identified in the mangosteen extract. Drug interaction potential was also simulated using rosiglitazone as a probe substrate for CYP2C8 and CYP2C9.
The results of the study demonstrate that mangosteen and its individual components have the ability to inhibit CYP activity. The authors emphasize that care should be taken when using mangosteen products in conjunction with certain prescription therapeutics and call for further studies to examine the wider phenomena of herb-drug interactions.
The paper, by Foti and colleagues at Amgen, is entitled ‘In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract.’
Please link to PubMed to view the abstract and full text options.