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New publication reviews physiologically-based pharmacokinetic modelling in paediatrics
Date: 14 Jan 2009
A new paper by Bouzom and Walther of Servier, provides the background to, and overview of, the recent roundtable discussion on the contribution of modelling in paediatric drug development which was held in Paris in July 2007.
The article explores the need for PBPK modelling in paediatric populations following recent EU legislation and highlights the limitations of allometric scaling in dose calculations for children. The authors review the literature detailing the known physiological changes which occur from birth to adulthood and outline how this knowledge has been applied to PBPK modelling in paediatrics. Two commonly used platforms for the prediction of PK changes in children are cited in the review including the paediatric module of the Simcyp population-based ADME Simulator.
The article, entitled ‘Pharmacokinetic predictions in children by using the physiologically-based pharmacokinetic modelling’, has been published in the journal Fundamental and Clinical Pharmacology. Please click here for a link to the abstract and full text options.