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New review describes Simcyp Advanced Dissolution, Absorption and Metabolism (ADAM) model
Date: 30 Apr 2009
An article published in the journal of the American Association of Pharmaceutical Scientists (AAPS) provides a detailed review of the Simcyp oral absorption model. The paper was written by Dr Masoud Jamei and his colleagues in the modelling and simulation group at Simcyp Limited.
The authors describe, in detail, how the bioavailability of drugs from oral formulations is influenced by physiological factors including gastrointestinal fluid composition, pH and dynamics, transit, motility, metabolism and transport. Furthermore, the influence of age, gender, ethnicity, food intake and disease on oral bioavailability, particularly of poorly soluble, poorly permeable or extensively metabolized compounds is discussed.
The approach presented in the paper allows variability in human populations to be incorporated in the assessment of oral bioavailability within a mechanistic framework. Examples highlighting some of the applications of the Simcyp ADAM model in drug and formulation development are also provided.
Please click here for a link to the abstract and the full text options.