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Pfizer study using Simcyp among ‘most downloaded’ British Journal of Clinical Pharmacology papers in May
Date: 20 Jun 2008
A recent publication by a team at Pfizer has topped the download list of the British Journal of Clinical Pharmacology. The research article published last month reports the results of a recent study undertaken to explore and optimise approaches for predicting clinical drug-drug interactions.
The study compared predictions using different in vitro data with results from clinical studies. The focus was on interactions which occur when substrates of CYP3A4 are co-administered with the CYP3A4 inhibitor, ketoconozole. The potential use of expressed systems instead of human liver microsomes was explored, particularly when investigational drugs are too stable in the latter. The Simcyp Population-based ADME Simulator was used as a platform for modelling and simulation throughout the investigation.
The Pfizer researchers concluded that the use of recombinant human CYP data with the Simcyp Simulator provides a “robust” system for predicting drug-drug interactions, pointing out that appropriate prediction systems “enable earlier and more informed management of a drug’s development plan.”
The paper is entitled, ‘Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.’ For the abstract and full text options please click here.