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Dr Trevor Johnson invited to ISSX Vienna
Date: 19 Dec 2007
Dr Trevor Johnson, senior scientist at Simcyp Limited and senior pharmacist at the Sheffield Children’s Hospital, has been invited to speak at the ISSX 10th Regional Meeting. The conference – ‘From microsomes via mice to man: drug development in the 21st century’ – will run from 18-21st May 2008, in Vienna, Austria.
Dr Johnson’s presentation will be entitled, ‘Incorporating information on CYP ontogeny into models for predicting drug disposition in children: the in silico child. How far away are we from reality?’ During his talk, Dr Johnson will describe the role that the Paediatric module of the Simcyp ADME Population-based Simulator has in developing drugs suitable for use in children.
Using the Simcyp Paediatric Simulator, modelling and simulation using in vitro data can be carried out for neonates, infants and children. In addition, simulations incorporate true population variability across the paediatric age range – a real advantage over making predictions for an ‘average’ child.
Traditionally, allometric scaling from adult data has been used to make predictions for paediatric patients; however, this is limited by the false assumption that children are simply ‘small adults’. Dr Johnson and his team have identified changes in pharmacokinetics which occur from birth onwards as a consequence of organ maturation, changes in body composition and the ontogeny of drug elimination pathways.
Dr Johnson will be available throughout the ISSX conference to give demonstrations of the latest version of the Simcyp Paediatric module and he welcomes any questions or discussions.