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Line of Management: Reports to Principal Scientist Systems Pharmacology Group
Position Type: Full Time
Holiday Entitlement: 25 days, plus statutory bank holidays
Salary: Commensurate with experience, plus pension contribution, health scheme etc.
We have an immediate opening for a Research Scientist within the Systems Pharmacology group. As a part of the Simcyp Science team you will be involved in research projects relating to the development of mechanistic ADME and PD models implemented within the Simcyp Simulator (particularly those for large therapeutic molecules, e.g. mAb, therapeutic proteins). Your role will involve collating, reviewing and analysing population, physiological, biological and clinical data for developing various PKPD and PBPK models including receptor mediated disposition and turn-over models. In addition you are expected to assist the project teams working on creating new disease population libraries by collating the necessary physiology data specific to the populations of interest. The successful applicant will join an internationally recognised, multidisciplinary team in which they will have the opportunity to further develop their knowledge and skills. We offer a unique and exciting mix of academic and commercial environments which encourages regular attendance at scientific meetings as part of continuous education programs. The projects are scientifically challenging yet focused on solving practical issues relevant to modern drug development. All scientists are expected to participate in writing scientific reports relevant to their work under the guidance of our world-leading senior scientists.
- PhD in Pharmacokinetics, Human Pharmacology or a closely allied discipline.
- A sound understanding of the clinical use of drug therapy.
- Demonstrable communication skills, as evident by presentation at scientific meetings.
- Some understanding of pharmacogenetics of drug metabolism, transport and receptor binding.
- The ability to collate and review data from scientific literature.
- Knowledge of pharmacokinetic properties of large molecule therapeutics.
- Confidence in the mathematical manipulation of data.
Simcyp is now part of Certara, a company which combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable ‘end-to-end’ solution in the quest for improving human health. The Simcyp team conducts cutting-edge research and provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases (implemented in its globally-recognised Simcyp Population-based Simulator) for a client base of major blue-chip pharmaceutical and biotechnology organisations. Simcyp focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the time-course and fate of drugs (ADME) and their action (pharmacological or otherwise) in patients using experimental data derived from in vitro systems such as isolated enzyme and cellular systems, dissolution media, cell lines etc. We are on course to become the global industry standard in predictive population ADME, consequently there is a continuous requirement for high quality scientists to join us, help in our expansion and share our success
Please send your CV, covering letter and the names of two references quoting [RES/May12/Sim] to:
- Post: Recruitment, Simcyp Limited (now Certara), Blades Enterprise Centre, John Street, Sheffield, S2 4SU United Kingdom