home > careers > pharmacologist/pkpd research scientist (two posts)
Pharmacologist/PKPD Research Scientist (two posts)
Sorry - this position is now closed
Line of Management: Reports to Principal Scientist
Hours of Work: Mon – Fri 9.00am – 5.00pm (1hr lunch time)
Holiday Entitlement: 25 days, plus statutory bank holidays
Salary: Commensurate with experience, plus pension contribution, health scheme etc.
Location: Sheffield (UK)
Company Overview:
Simcyp is a fast-growing, research-based company that provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases relevant to drug development (implemented in its world-known Simcyp Population-based ADME Simulator) for its client base of major blue-chip pharmaceutical and biotechnology organisations. The company focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the time-course and fate of drugs (ADME) in patients using experimental data derived from in vitro systems such as isolated enzyme and cellular systems, dissolution media etc. We are on course to become the global industry standard in predictive population ADME, consequently there is a continuous requirement for high quality scientists to join us, help in our expansion and share our success. We offer a unique and exciting mix of academic and commercial environments which encourages regular attendance at scientific meetings as part of continuous education programs. The projects are scientifically challenging yet focused on solving practical issues relevant to modern drug development. All scientists are expected to participate in writing scientific reports relevant to their work under the guidance of our world-leading senior scientists within the group.
Job Overview:
We have immediate openings for two Pharmacologists/PKPD Research Scientists who are keen to apply their skills to support the development of models of disease and pharmacodynamic (PD) response, bridging mechanistic and semi-empirical approaches to the simulation of drug action in different populations. The roles involve both the development and the application of models, building on the pharmacokinetic (PK) simulation and parameter optimization capabilities of the Simcyp Population-based ADME Simulator. Candidates should have experience in some of the following areas: receptor pharmacology experiments/theory, clinical pharmacology, systems biology, genetic and other physiological regulatory mechanisms, data analysis or modelling in pharmacokinetics/pharmacodynamics (PKPD).
The successful applicants will join an internationally recognised, multidisciplinary team in which they will be expected to take part in developing models and algorithms within the current framework of modelling and simulation guided by the Simcyp Consortium.
Requirements:
- Preferably a higher degree (or equivalent experience) in a relevant field: Pharmacology; PKPD; Toxicology; Physiology; Medicine; Biomedical Sciences.
- Demonstrable communication skills, as evident by history of presenting at scientific meetings and/or publication in peer-reviewed journals, with good interpersonal and organizational skills.
- Work experience and knowledge of pharmacology including receptor mechanisms, in vitro experiments, regulatory physiology, disease models, biomarkers, PKPD.
- Industrial experience/previous working knowledge of commonly used PKPD or computational biology tools would be advantageous.
- Some understanding of a programming language such Fortran/C/C++/C# is preferable but not essential.
Applications:
Please send your CV, covering letter (quoting ref: Sim/Res/May10) and names of two references to recruitment@simcyp.com, or post to:
Recruitment
Simcyp Limited
The Blades Enterprise Centre
John Street
Sheffield, S2 4SU
United Kingdom